A Sinus Sufferer’s Guide to Supplements

By Nutritional Weight & Wellness Staff
April 20, 2020


Updated: May 2, 2023

Spring has sprung, be it a little belated in Minnesota where we’re located, which means people’s spring allergies are in full bloom. Does this time of year bring you a stuffy or runny nose, itchy and watery eyes, a pounding headache, sinus pressure, and an inability to go outside without sneezing? 

Avoiding your allergens is the best way to avoid allergy symptoms, but when pollen counts are high, what do you do to not feel uncomfortable?  Your doctor may prescribe a second-generation antihistamine (such as, Claritin, Zyrtec or Allegra), a decongestant and/or a nasal antihistamine spray. As with any medication, these may come with some potential side effects such as drowsiness, dry mouth, constipation, or trouble urinating (especially in men with prostate issues). If you are looking for additional options for relief this year, you may consider a natural supplement to help manage  your allergy symptoms.

First, A Bit About Histamine and How Antihistamines Work

For seasonal allergy sufferers’, pollen in the environment meets up with mucosal cells in the nose, mouth, throat, lungs, stomach, and intestines.  The immune system triggers the release of a chemical called histamine. In extreme situations, most often seen with food allergies, the allergic reaction can be life-threatening. It may result in extreme swelling in the respiratory tract making it difficult to breath and/or a person may have a serious drop in blood pressure.

The flood of histamine can impact the gut, leading to sudden stomach pain, bloating, vomiting, and/or diarrhea. It could even stimulate the release of stomach acid and may result in symptoms of heartburn or indigestion. Additionally, histamine can cause the unpleasant, less extreme symptoms we associate with seasonal allergies like a runny nose and itchy eyes. You might also be surprised to learn that histamine is  found naturally in some of the foods we eat.   

Antihistamines work by blocking histamine activity and stopping allergic reactions. Certain foods and plant extract may act like antihistamines and stop the effects of histamine, which can be used to support yourself during allergy season.

High histamine symptoms:

  • Runny or itchy nose
  • Sneezing or post nasal drip
  • Itchy, red, or watery eyes
  • Itchy ears
  • Itchy or inflamed skin (like hives or rashes)
  • Heartburn or indigestion (like stomach pain, bloating, vomiting, diarrhea)
  • Difficulty breathing, wheezing, aggravated asthma
  • Drop in blood pressure

A Natural Antihistamine Option

Natural D-Hist, by Ortho Molecular, is probably our most popular allergy-fighting supplement. The combination of quercetin, vitamin C, bromelain, and stinging nettle is very good at calming the body’s immune system and preventing an overreaction to pollen. Quercetin, in case it’s new for you, is an antioxidant; it is naturally found in some fruits and vegetables such as citrus fruits, onions, and apples.

For kids who suffer from allergies, Ortho Molecular also makes D-Hist Jr. which has the same ingredients as Natural D-Hist, just at smaller dose that is more appropriate for smaller bodies in an easy-to-chew tablet. Adults can also take this chewable form too!

Dosage: Many clients take 2 capsules of Natural D-Hist 2-3 times per day for 10 days as a loading dose during peak allergy time and continue taking 1-3 capsules daily as a maintenance dose. With D-Hist Jr., the dose is 1-3 tablets per day.

D-Hist keeps my sinuses clear and healthy. It is my #1 supplement I can’t be without! I use to suffer from sinus infections twice a year and thanks to D-Hist, my sinuses stay healthy. I have taken D-Hist for over 8 years and will continue for years to come!” – Jayne K on Natural D-Hist

“Awesome product! This works wonders for Histamine Intolerance, and combined with zinc is great in Covid prevention and treatment! It’s also great to combat seasonal allergies…our whole family loves it!” – Allison on D-Hist JR

There are some possible safety concerns with high doses of quercetin related to the risk of kidney damage. People who have decreased kidney function and those who are pregnant or nursing should not take quercetin supplements. As with any supplements, we recommend talking with your doctor and dietitian or nutritionist before adding it into your routine.

Sinus Pain and Inflammation Support

Sinatrol contains n-acetyl cysteine, thyme, and bromelain, which help the body clear airway passages by thinning mucus secretions. Think of them as natural forms of Mucinex®. The turmeric and licorice root extract in Sinatrol help reduce sinus inflammation and strengthen the immune system so that it is not overwhelmed by excess pollen or mold.

Dosage: We recommend clients take the recommended dosage of 3 capsules per day.

“Life Changing! I've had bad allergies and post nasal drip for almost 10 years now and I thought I'd always have to deal with these annoying issues. Allergy meds always make my heart flutter and I always feel strange when taking them but this product has no side effects for me!” -Danielle 

Side note: If you are currently being treated with any blood-thinning medications you should not take Sinatrol without first talking with your doctor since it contains turmeric. We recommend anyone considering adding a supplement to their routine speak with their doctor and dietitian or nutritionist first to make sure it’s right for you.

Sinus Relief Meal Plan

Many Nutritional Weight & Wellness clients find that supplements taken during their peak allergy season (and ideally starting before peak!) are a good start to reducing their symptoms. Using a nasal saline mist, showering nightly to wash pollens out of your hair and changing your bedsheets on the regular are additional good practices that generally work for most people. The food you choose to eat plays a HUGE role in supporting your immune system as well, so: eat real food!

To help you find relief with your sinuses, try a few of these nutrition-focused changes:

  • Fresh is ideal. Enjoy fresh, minimally processed foods. Histamine will develop in protein foods as they age. In general, histamine content of food goes up as food ages/spoils. If you already have more histamine in your system due to seasonal allergies, a leftover meal high in histamine may result in worsening symptoms. Now, don’t go throwing your leftovers away! Those make great lunches! Instead, try to eat your food fresh and then freeze leftover proteins right away to help slow histamine production.
  • Minimize or avoid ultra processed foods that are rich in preservatives, additives, and alcohol. Yes – alcohol! Alcohol hinders the enzyme (DAO) that is needed to degrade histamine in the body.  Red wine and beer are also high in histamine, so consuming those can feel like adding fuel to the fire.
  • Limit added sugar and processed carbs like sweets, breads, crackers, chips, bagels, etc. All of these can increase inflammation in the body.
  • Remove dairy for 1-2 weeks to see if that makes a difference in symptoms. Those who have a sensitivity to dairy can have more inflammation and the potential for more mucus production when consuming things like cheese and yogurt. 
  • Trial the elimination of gluten. Gluten is a protein found in wheat, barley, rye, and oats that are not labeled gluten free. Gluten can increase intestinal permeability, cause an immune response in the body, and harm the gut if you have a sensitivity. And the gut is related to your immune system, which is related to your sinuses!

Nutrition tips to relieve allergy symptoms:

  1. Eat fresh real food
  2. Minimize ultra-processed foods and alcohol
  3. Limit or cut back on added sugar and processed carbs
  4. Test removing dairy for 1-2 weeks
  5. Experiment with eliminating gluten

Here are some ideas for meals that are not only delicious but can also support relief during this sneezy season!

Relief From Suffering This Spring

To recap, consider making some adjustments to your nutrition to reduce inflammation and irritation by focusing on fresh, minimally processed foods and cutting out ultra-processed foods with added sugar. Freezing leftover proteins and trialing no dairy and no gluten may also prove beneficial. Before and especially during peak allergy season, try some natural supplement options. If you’re still struggling, make an appointment with a nutritionist or dietitian to help look at your symptoms and problem-solve some additional options you can try.

Learn more about sinus relief with these free resources:

About the author

This blog content was written by a staff member at Nutritional Weight & Wellness who is passionate about eating real food.

View all posts by Nutritional Weight & Wellness Staff


Can I give my 3 year old D Hist Jr and Zyrtec together? I’ve been giving him a d hist at night and then 5ml of Zyrtec in the morning; seems to work pretty well except in peak allergy season, he needs more.
May 20, 2018 at 10:55 am


If D-Hist Jr. is not alleviating symptoms on its own it should be safe to use it alongside another over the counter medication as you are when allergy season is at its height.

Heidi Golderg
My 12 year old son had sinus congestion and a cough in mid December. After it got much worse after 3 weeks, the Dr. put him on antibiotics and prednisone. He got better, but then a few weeks later he started again with nasal congestion and a cough. The cough has gone away but he still has constant lingering nasal congestion and it's now mid February. I don't want him to go back on antibiotics or prednisone. I have him on Elderberry, Vit C, multivitamin and probiotics. I also had him allergy tested and it came back negative. Can I try Sinatrol with him or is it only for adults? He is 12 years and 100 lbs. Would that help?
February 14, 2019 at 2:44 pm


Sorry to hear you have been dealing with this for so long.  I recommend a gluten and dairy free diet as well as low in sugar.  In addition, you may want to try 4 D-Hist per day for 6 - 10 days and 1T of Aqua Flora phase I in the morning. If you would like even further personalized guidance you can make a one on one appointment with one of our Nutritionists.

Grace Nthara
I have chronic sinusitis and tired of antibiotics.
Please I need advise from you.

March 15, 2019 at 4:31 am


Sorry to hear you have been dealing with Sinusitis for so long. Any of our nutritionists would be able to give you great guidance and a personalized food and supplement plan to help you with these symptoms in a one-on-one nutrition appointment in person, or via phone or Skype.

Eduardo Espinola
My sinuses always disturbing me my voice is not clear and poweless
March 18, 2019 at 8:51 pm


So sorry to hear you are dealing with these bothersome symptoms. You could also listen to this podcast. If you would like more personalized guidance then the article and podcast here we would suggest setting up a one-on-one nutrition consultation in-person, by Skype, or phone to help manage these symptoms.

I have been suffering from Sinus Headache and nasal blockade during last 20 years even after two sinus operations .
My main problem is sinus infection .
Should I take Sinatrol ? / or /, anything else ?
Could you please advise me .
May 11, 2019 at 7:42 am


I am so sorry to hear you have struggled with painful inflamed sinuses. I would start with diet first. Remove all dairy, gluten, and sugar.  Eat real foods. Sinotrol 3-6 capsules per day.  If you do not find relief please make an appointment with a nutritionist to help with this challenging problem.

Hi, I have been frequently suffering from sinusitis, driven by allergy, it would usually occur when the season changes to spring, fall and winter, and the cold weather makes it worse. Read your article regarding supplements, and wonder which one am I better taking, the Natural D-Hist or Sinatrol ? I really want to also strengthen my immunity against it so i don't suffer everytime. Would appreciate your advice please. Thank you.
May 29, 2019 at 9:23 pm


We would recommend starting with the D-Hist, be sure to do the loading dose as directed on the bottle for best results. We’d also recommend taking a probiotic to strengthen your immune system.

Hi, appreciate your response, thank you very much. With the D-Hist, after the loading dosage, what can you advice in regards the maintenance dosage please, like how often and how long do I need to take?
And in regards, taking a probiotic, would that specifically be an Immune System probiotic? Is there one in particular that you can recommend please? As there are a lot of probiotics available in the market these days and I've read that if you take not the correct one, it might just cause you more problems.
Look forward to your response and appreciate your guidance.
Thank you very much.
May 30, 2019 at 9:48 pm


1-2 caps of D-Hist per day is the maintenance dose and many people just take it during allergy season, it does say this on the label but just a reminder to take the D-Hist away from food. All probiotics will help to boost your immune system because 70-80% of your immune system is found in your intestinal tract. I would recommend getting at least 15 billion CFU from a probiotic. You could start with the Bifido Balance 6 caps per day or ½ tsp of the Bifido Powder per day either right away in the morning or before bed and then after a few months switch to our Biotic 7 which would just be 1 capsule per day.

Hi, if i’m taking the Natural D-hist, while on the loading dosage, do i still need to take vitamin C or will the d-hist be enough?
Thank you
June 14, 2019 at 1:10 am


You can discontinue if you wish but It would be just fine to continue taking additional Vitamin C with the Natural D-hist as well.

I am taking a probiotic with enzyme blend and ginger. Would taking sinatrol over do what the probotic is giving? I just order the D Hist and aqua flora to start taking for my sinus allergies issues.

Thank you

June 28, 2019 at 12:06 pm


Although I am not familiar with this particular probiotic there is no contraindications for taking the  DHist and the Aqua Flora.  I would however, recommend the Probiotic is taken on an empty stomach 30 minutes prior to the other supplements.  You can also take the probiotic before bed as well.

Beverly Davis
I keep getting staff infection in my sinus. Have had 2 surgeries. Taken antibiotics predozone. I need a good supplement. I think i have an autoamun
October 10, 2019 at 6:31 pm


That sounds very uncounterable, we are sorry to hear you are dealing with this. Without knowing more health history and information we are not able to suggest one supplement that would be best for you, it can vary greatly from person to person especially with autoimmune disease. The best thing to do would be to set up a one-on-one appointment with one of our nutritionists in-person if you live in the twin-cities or via phone or skype. 

Nancy Socha
My daughter has a chronic sinus problem where polyps develop. She has had 7 surgeries to remove calcified polyps. She will be away for six months and needs immune calming supplements. Do you suggest Aqua Flora and Sinatrol ?
March 9, 2020 at 4:00 pm


Thank you for your inquiry.  I do not believe the Aqua Flora or the Sinatrol will be the answer to improve her immune system.

I recommend sending her off with Vitalzyme, Zinc and Omega-3 Fish Oils.  Vitalzyme, to help decrease scar tissue and prevent more calcification, zinc to improve immune system and omega-3’s to keep inflammation to a minimum. 

Can you take D Hist and Sinatrol together or do they counteract each other when trying to thin mucus and decrease inflammation?
April 15, 2020 at 7:56 am


Yes, you can take D-Hist and Sinatrol together. They contain different beneficial ingredients to help reduce sinus inflammation.

Lori V.
I have had chronic sinusitis for over 10 years and symptoms are worse on days when there is a cold dry-front that moves in. I have some reprieve on days when it is warm and somewhat humid. I had surgery earlier this year (6 or 7 months ago) and had 3 GLORIOUS months of no symptoms at all. Dr. removed a large cyst, bone spur, fixed deviated septum and overall cleaning out of sinuses. On days where I'm down-for-the count, it seems that my mucus is thick and not draining no matter what I take...it doesn't help. Which of your products would help with not drying out the sinuses and thin the mucus? Thank you!
June 16, 2020 at 9:16 am


Sinatrol would be worth a try; take 3 caps per day away from meals. If you haven't already I would highly suggest eliminating dairy, including butter, to see if that helps. 

Hi My daughter is pregnant, she has suffered with chronic stuffy nose forever. What can she take for relief?
July 1, 2020 at 8:58 am


Pregnancy is hard to make general recommendations. We can’t recommend a lot of supplements. She really needs to make an appointment. The only thing that would be safe trying without an appointment is a trial of dairy-free eating. She would need to make sure she is still getting plenty of protein and taking a good prenatal vitamin. Again, an appointment is highly recommended.

Hi ,
I have very bad post nasal drip . I am currently taking vit c , NAC , probiotics and seabuck thorn oil . I also take zyrtec D in the night so I will not get congestion in the morning. is this harmful for the liver and kidneys??? can i take zrytec for long term like 6 months?
November 10, 2020 at 7:28 pm


These questions are probably best for a pharmacist or your doctor.

Hi, do you have a specific brand that you can recommend for safe consumption for Natural D-Hist? I was looking to buy from iherb but it is discontinued. Just worried why has it been discontinued? Because of any safety reason?

November 30, 2020 at 12:18 am


You can find it on our NutriKey website here 

Hi I am a 37 yr old woman I have asthma and recently started suffering from extreme sinus problems and infections, also just diagnosed with polyps. I have been on Flonase for 3 months steam and irrigation twice a day. I am in constant pain and headaches 80 percent of 5he time, the Flonase helped for a bit then they came back with a vengeance actually changing the way I looked I put my self on predisone as my doctor keeps prescribing useless steroids I actually went to the ear and they prescribed the Flonase. I was on the prednisone for 2 weeks it helped 100 percent I have been off prednisone for almost 2 weeks and am started to feel the sides of my nostrils slightly tough once again. I take vit c multivitamin and zinc. Is there anything you can suggest. I have made multiple requests to see a specialist even went to the hospital and can not get any help. Any advice would be greatly appreciated!
March 30, 2021 at 11:19 pm


For the sinuses, I’d start with removing all dairy from the diet if not already dairy-free, and taking sinatrol (3 caps/day, away from food). Consider removing gluten-containing grains also (wheat, barley, rye, oats). I’d recommend making an appointment with one of our counselors to do a deeper dive into reasons for a compromised immune system (like poor gut health).

My son age 17 years has been having sinuses, coughing, running nose always, painful eyes and clicking of ears. It makes even not concentrate in class and also fail in exams.Which supplement is best for him? I also need him to perform in school.
April 26, 2024 at 3:52 pm


I would recommend getting rid of the added sugar and processed food in his diet. A trial of a dairy free and/or gluten free diet could also be beneficial. For supplements, I would recommend starting with the loading dose of D-Hist and a probiotic like Bifido.

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